Induction of broadly neutralizing H1N1 influenza antibodies by vaccination.
Identifieur interne : 000E67 ( Main/Exploration ); précédent : 000E66; suivant : 000E68Induction of broadly neutralizing H1N1 influenza antibodies by vaccination.
Auteurs : Chih-Jen Wei [États-Unis] ; Jeffrey C. Boyington ; Patrick M. Mctamney ; Wing-Pui Kong ; Melissa B. Pearce ; Ling Xu ; Hanne Andersen ; Srinivas Rao ; Terrence M. Tumpey ; Zhi-Yong Yang ; Gary J. NabelSource :
- Science (New York, N.Y.) [ 1095-9203 ] ; 2010.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (biosynthèse), Anticorps antiviraux (immunologie), Anticorps neutralisants (biosynthèse), Anticorps neutralisants (immunologie), Femelle, Furets, Glycoprotéine hémagglutinine du virus influenza (génétique), Glycoprotéine hémagglutinine du virus influenza (immunologie), Grippe humaine (), Grippe humaine (immunologie), Humains, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Macaca mulatta, Mâle, Plasmides, Protection croisée, Protéines mutantes (immunologie), Rappel de vaccin, Souris, Souris de lignée BALB C, Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H2N2 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (immunologie), Vaccination, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Vaccins à ADN (administration et posologie), Vaccins à ADN (immunologie), Vecteurs génétiques.
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins à ADN.
- biosynthèse : Anticorps antiviraux, Anticorps neutralisants.
- génétique : Glycoprotéine hémagglutinine du virus influenza.
- immunologie : Anticorps antiviraux, Anticorps neutralisants, Glycoprotéine hémagglutinine du virus influenza, Grippe humaine, Infections à Orthomyxoviridae, Protéines mutantes, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux, Vaccins à ADN.
- Animaux, Femelle, Furets, Grippe humaine, Humains, Infections à Orthomyxoviridae, Macaca mulatta, Mâle, Plasmides, Protection croisée, Rappel de vaccin, Souris, Souris de lignée BALB C, Vaccination, Vecteurs génétiques.
English descriptors
- KwdEn :
- Animals, Antibodies, Neutralizing (biosynthesis), Antibodies, Neutralizing (immunology), Antibodies, Viral (biosynthesis), Antibodies, Viral (immunology), Cross Protection, Female, Ferrets, Genetic Vectors, Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Immunization, Secondary, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H3N2 Subtype (immunology), Influenza A Virus, H5N1 Subtype (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Influenza, Human (immunology), Influenza, Human (prevention & control), Macaca mulatta, Male, Mice, Mice, Inbred BALB C, Mutant Proteins (immunology), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Plasmids, Vaccination, Vaccines, DNA (administration & dosage), Vaccines, DNA (immunology).
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, DNA.
- chemical , biosynthesis : Antibodies, Neutralizing, Antibodies, Viral.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , immunology : Antibodies, Neutralizing, Antibodies, Viral, Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Mutant Proteins, Vaccines, DNA.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A Virus, H5N1 Subtype, Influenza, Human, Orthomyxoviridae Infections.
- prevention & control : Influenza, Human, Orthomyxoviridae Infections.
- Animals, Cross Protection, Female, Ferrets, Genetic Vectors, Humans, Immunization, Secondary, Macaca mulatta, Male, Mice, Mice, Inbred BALB C, Plasmids, Vaccination.
Abstract
The rapid dissemination of the 2009 pandemic influenza virus underscores the need for universal influenza vaccines that elicit protective immunity to diverse viral strains. Here, we show that vaccination with plasmid DNA encoding H1N1 influenza hemagglutinin (HA) and boosting with seasonal vaccine or replication-defective adenovirus 5 vector encoding HA stimulated the production of broadly neutralizing influenza antibodies. This prime/boost combination increased the neutralization of diverse H1N1 strains dating from 1934 to 2007 as compared to either component alone and conferred protection against divergent H1N1 viruses in mice and ferrets. These antibodies were directed to the conserved stem region of HA and were also elicited in nonhuman primates. Cross-neutralization of H1N1 subtypes elicited by this approach provides a basis for the development of a universal influenza vaccine for humans.
DOI: 10.1126/science.1192517
PubMed: 20647428
Affiliations:
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Le document en format XML
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BALB C</term><term>Vaccination</term><term>Vecteurs génétiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The rapid dissemination of the 2009 pandemic influenza virus underscores the need for universal influenza vaccines that elicit protective immunity to diverse viral strains. Here, we show that vaccination with plasmid DNA encoding H1N1 influenza hemagglutinin (HA) and boosting with seasonal vaccine or replication-defective adenovirus 5 vector encoding HA stimulated the production of broadly neutralizing influenza antibodies. This prime/boost combination increased the neutralization of diverse H1N1 strains dating from 1934 to 2007 as compared to either component alone and conferred protection against divergent H1N1 viruses in mice and ferrets. These antibodies were directed to the conserved stem region of HA and were also elicited in nonhuman primates. Cross-neutralization of H1N1 subtypes elicited by this approach provides a basis for the development of a universal influenza vaccine for humans.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Andersen, Hanne" sort="Andersen, Hanne" uniqKey="Andersen H" first="Hanne" last="Andersen">Hanne Andersen</name><name sortKey="Boyington, Jeffrey C" sort="Boyington, Jeffrey C" uniqKey="Boyington J" first="Jeffrey C" last="Boyington">Jeffrey C. Boyington</name><name sortKey="Kong, Wing Pui" sort="Kong, Wing Pui" uniqKey="Kong W" first="Wing-Pui" last="Kong">Wing-Pui Kong</name><name sortKey="Mctamney, Patrick M" sort="Mctamney, Patrick M" uniqKey="Mctamney P" first="Patrick M" last="Mctamney">Patrick M. Mctamney</name><name sortKey="Nabel, Gary J" sort="Nabel, Gary J" uniqKey="Nabel G" first="Gary J" last="Nabel">Gary J. Nabel</name><name sortKey="Pearce, Melissa B" sort="Pearce, Melissa B" uniqKey="Pearce M" first="Melissa B" last="Pearce">Melissa B. Pearce</name><name sortKey="Rao, Srinivas" sort="Rao, Srinivas" uniqKey="Rao S" first="Srinivas" last="Rao">Srinivas Rao</name><name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M" last="Tumpey">Terrence M. Tumpey</name><name sortKey="Xu, Ling" sort="Xu, Ling" uniqKey="Xu L" first="Ling" last="Xu">Ling Xu</name><name sortKey="Yang, Zhi Yong" sort="Yang, Zhi Yong" uniqKey="Yang Z" first="Zhi-Yong" last="Yang">Zhi-Yong Yang</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Wei, Chih Jen" sort="Wei, Chih Jen" uniqKey="Wei C" first="Chih-Jen" last="Wei">Chih-Jen Wei</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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